Proviron compensates for the lack of androgens, the production of which gradually decreases with age. Therefore, Proviron offers a treatment for conditions caused by a lack or complete lack of androgen production in the body. It does not reduce sperm production at the recommended doses. This medicinal product is not hepatotoxic.
After oral administration, mesterolone is quickly and almost completely absorbed in the dose range of 25-100 mg. The maximum serum concentration is 3.1 ± 1.1 ng/ml and is reached after 1.6 ± 0.6 hours after detection. As a result, serum drug levels fall 12-13 hours after the terminal half-life, with 98% of masterolone binding to plasma proteins, 40% to albumin, and 58% to sex hormone-binding globulin. (SHBG).
Nesterol is rapidly metabolized
The metabolic clearance of the serum is 4.4 ± 1.6 ml/min -1 /kg -1 . It is excreted by the kidneys only as metabolites. The major metabolite is 1α-methylandrosterone in its bound form, accounting for 55-70% of the metabolites excreted by the kidney. The ratio of its main metabolite glucuronide to sulfate is about 12.1. Another metabolite is 1α-methyl-5α-androstane-3α,17β-diol, which accounts for about 3% of the metabolites and is excreted through the kidneys.
No metabolic conversion to estrogen or corticosteroids was observed. About 80% of a mesterolone dose is excreted as metabolites in the urine and about 13% in the faeces. 93% of the dose is excreted in the urine within 7 days, half of it in the urine within 24 hours.
Each tablet contains 25 mg of mosterol,
Lactose Monohydrate, Corn Starch, Povidone, Methylparaben (E218), Propyl Hydroxybenzoate (E216), Magnesium Stearate.